Polymyxin B Etest Fails to Distinguish Carbapenem-resistant Enterobacteriaceae with Elevated Polymyxin B MICs
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منابع مشابه
Colistin and Polymyxin B Susceptibility Testing for Carbapenem-Resistant and mcr-Positive Enterobacteriaceae: Comparison of Sensititre, MicroScan, Vitek 2, and Etest with Broth Microdilution.
Colistin and polymyxin B remain part of the last line of antibiotics for multidrug-resistant Gram-negative bacteria, such as carbapenem-resistant Enterobacteriaceae Current joint EUCAST-CLSI recommendations are for broth microdilution (BMD) to be performed for MIC testing of colistin. Commercial susceptibility testing methods were evaluated and compared against the reference BMD, using a suscep...
متن کاملDecreased susceptibility to polymyxin B during treatment for carbapenem-resistant Klebsiella pneumoniae infection.
In the United States, the major mechanism of carbapenem resistance among Enterobacteriaceae is the production of Klebsiella pneumoniae carbapenemase (KPC) (2). Polymyxins and tigecycline are the antimicrobials most often used for treatment of infections caused by carbapenem-resistant Enterobacteriaceae (4, 11). Polymyxin B, discovered more than 60 years ago, has been reintroduced as a valuable ...
متن کاملIn-Vitro Activity of Polymyxin B, Rifampicin, Tigecycline Alone and in Combination against Carbapenem-Resistant Acinetobacter baumannii in Singapore
OBJECTIVE Carbapenem-resistant Acinetobacter baumannii (CR-AB) is an emerging cause of nosocomial infections worldwide. Combination therapy may be the only viable option until new antibiotics become available. The objective of this study is to identify potential antimicrobial combinations against CR-AB isolated from our local hospitals. METHODS AB isolates from all public hospitals in Singapo...
متن کاملCarbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents.
OBJECTIVES To describe the molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in Brooklyn, NY and assess the in vitro activity of various antibiotic combinations. METHODS Clinical isolates with suspected carbapenem resistance were referred to the central research laboratory from August 2003 to June 2004. Isolates underwent MIC testing, ribotyping, and were analysed for the p...
متن کاملTreatment of Hospital or Ventilator-Associated Pneumonia Due to Carbapenem-Resistant Enterobacteriaceae: Leveraging Molecular Resistance Testing and Combination Therapy to Improve Outcomes.
TO THE EDITOR—The recently published updated Infectious Diseases Society of America guideline on the management of adults with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) recommend that patients with HAP/VAP due to “carbapenem-resistant pathogens” susceptible only to polymyxins should receive, in addition to colistin by inhalation, systemic monotherapy with eithe...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017